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Sep 2026

Click-crosslinked arginine-based nanoplatform for co-delivery of camptothecin and siSTAT3 for metastatic breast cancer therapy.

Metastatic breast cancer remains a major therapeutic challenge due to the limited efficacy of current treatments against both primary tumors and distant metastases. Here, we developed an arginine-based click-crosslinked nanoplatform for the co-delivery of camptothecin (CPT) and STAT3 siRNA (siSTAT3). The nanoplatform w...

Su-Bin Xiong, Jing-Heng Xiang, Xiao He et al. · 0 citations
Aug 2026

Cascade-responsive biomimetic nanoparticles remodel tumor metabolism and potentiate ferroptosis for synergistic therapy of aggressive breast cancer.

In vitro and in vivo evaluations confirm that R-A/G@Z effectively suppresses aggressive breast tumors while maintaining a good safety profile, offering a promising strategy for intelligent metabolic-chemodynamic cancer nanomedicine.

Nian-Ting Xiao, Xiao He, Da-Xiu Li et al. · 0 citations

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