Author

Xiao-Hong Gu

2 papers indexed here

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Sep 2026

Levistilide A alleviates pulmonary fibrosis by blocking the cation channel PIEZO1-centered signaling pathway in fibroblasts.

BACKGROUND Pulmonary fibrosis (PF) is a common pathological feature of various chronic lung diseases, characterized by destruction of lung parenchyma and alveolar structure, aberrant angiogenesis and fibroblast proliferation. Therefore, determining the main contributing factors of PF and finding effective targeted medi...

Qi Han, Ran-Yun Chen, Yun Yang et al. · Phytomedicine · 0 citations

Open access Sep 2026

High-Calorie Diet Aggravates Lipopolysaccharide-Induced Pulmonary Inflammation in Juvenile Mice: Association of Acetate-Mediated Macrophage Polarization with AMPK/YAP Signaling

Macrophage polarization is an important modulator of the progression, severity, and resolution of pediatric pneumonia. Acetate, a metabolite produced by the gut microbiota, serves as a key regulator of macrophage polarization. Evidence demonstrates that a high-calorie diet (HCD) lowers acetate levels, thereby aggravati...

F. Sun, Hui Liu, Shu-Xuan Li et al. · Nutrients · 0 citations