Review
Open access
Sep 2026
Rewriting the genome: harnessing R2 retrotransposons for precise DNA insertion
CRISPR-based genome editors are fundamentally limited by their requirement for double-strand DNA breaks (DSBs), restricted transgene cargo capacity, and reliance on error-prone endogenous DNA repair mechanisms. Non–long terminal repeat (non-LTR) retrotransposons—especially the site-specific R2 element—offer a mechanist...
Liang-Zheng Fu, Ya-Chao Wu, Xiao-Hua Jin et al.
· Frontiers in Genome Editing · 0 citations