Xiao-Hui Liu

Lentinan-induced FUBP1 O-GlcNAcylation suppresses macrophage ferroptosis and atherosclerosis via the Tp53/SLC7A11 axis.

Atherosclerosis remains a leading cause of cardiovascular mortality, driven by macrophage dysfunction and necrotic core expansion. Ferroptosis, an iron-dependent cell death, is a critical driver of plaque instability; however, pharmacological interventions targeting ferroptosis remain scarce. Lentinan (LNT), a bioactiv...