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[This corrects the article DOI: 10.1371/journal.pone.0356002.].
WNT1 and S100A8, which are associated with apoptosis, play critical roles in both inflammatory bowel disease and osteoporosis, providing new potential therapeutic targets and a theoretical basis for clinical diagnosis and treatment.
The net skeletal effect of the immune system is determined by the balance of interacting cell types, cytokine networks, and signaling pathways, and systematic evaluation of combination strategies pairing immunomodulators with anti-resorptive, anabolic agents, or senolytics.
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