Review
Sep 2026
Emerging strategies for regulating Cas12a and Cas13a trans-cleavage activity in biosensing.
This review summarizes recent advances in the molecular basis and activity regulation of CRISPR-Cas12a- and Cas13a-based biosensing systems and aims to provide a framework for designing more controllable and adaptable CRISPR trans-cleavage biosensing systems.
Xiao-Hui Wang, Ya-Ru Huang, Lei Zhang et al.
· Biotechnology Advances · 0 citations