Open access
Aug 2026
Orthogonal DNA barcoding enables subpopulation-resolved extracellular vesicle miRNA profiling
Extracellular vesicle–associated microRNAs (EV-miRNAs) hold promise for liquid biopsy, but their clinical utility is hindered by EV heterogeneity. Here, we report DEEPER, a DNA-encoded orthogonal recognition platform for selective barcoding of tumor-derived EV subpopulations and in situ miRNA profiling. DEEPER uses fou...
Ye Zhang, Yi-Tong Zhu, Yu Zhang et al.
· Science Advances · 0 citations