Author

Xiao-Jie Yu

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Open access Aug 2026

P53 Competitively Binds P300 to Suppress HIF‐1α/TFRC‐Mediated Ferroptosis and Promote Doxorubicin Resistance in Breast Cancer

P53 promotes DOX resistance by suppressing HIF‐1α/P300‐mediated TFRC transcription and TFRC‐dependent ferroptosis, highlighting the P53/P300/HIF‐1α/TFRC axis as a potential therapeutic target in DOX‐resistant breast cancer.

Xiao-Jie Yu, L. Yao, Shu-Chun Zhang et al. · The FASEB Journal · 0 citations

Open access Jul 2026

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

A previously unrecognized transcription‐ubiquitination cascade that modulates Hippo signaling and contributes to breast cancer progression is revealed, highlighting this axis as a candidate therapeutic vulnerability that warrants further validation for limiting metastasis.

An Xu, Xiang-nan Xu, Xiao Huang et al. · Advancement of science · 0 citations