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Open access Sep 2026

Therapeutic Potential of iPSC-Derived TH⁺/FOXA2⁺ Neuronal Extracellular Vesicles in Parkinson’s Disease Revealed by Organoid and Rodent Models

Background Parkinson’s disease (PD) is characterized by the progressive loss of midbrain dopaminergic (DA) neurons and aberrant α-synuclein (α-syn) aggregation, yet disease-modifying therapies that simultaneously retard neurodegeneration and foster regeneration remain lacking. Methods In this study, we isolated extrace...

Zhen Qi, Xiao-Wen Li, Xiao Jin et al. · 0 citations
Review Open access Jul 2026

Human cardiac organoids: multidimensional integration and clinical translation potential

This article adopts a multi-dimensional integration perspective to systematically summarize innovative breakthroughs in the construction of cardiac organoids through intelligent biomanufacturing, neuro-vascular-immune co-construction, and single-cell omics.

Xiao Jin, Xin-Yue Ding, Zong-Jun Liu · 0 citations

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