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Xiao-Jing Wang

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Open access Oct 2026

Evidence of active whole-genome doubling (WGD) subclones in non-WGD tumors

Whole-genome doubling (WGD) occurs frequently in human cancer and influences tumor evolution, metastasis, and treatment response. Here, we integrate bulk, single-cell, and spatial data to dissect the subclonal dynamics of WGD. Single-cell data analysis shows that WGD cells are prevalent even in tumors that are classifi...

Fu-Nan He, M. Noureen, E. Dray et al. · 0 citations

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