EZH2 in Ovarian Cancer: Mechanistic Dependencies, Therapeutic Platforms and Translational Combinations.
INTRODUCTION/OBJECTIVE Ovarian cancer remains the deadliest gynecologic malignancy because most patients present with advanced disease and ultimately relapse despite surgery, platinum- based chemotherapy, and modern maintenance strategies. Enhancer of zeste homolog 2 (EZH2), the catalytic core of polycomb repressive co...