Avian influenza viruses of the H5Nx subtype pose persistent pandemic threats. Here, we immunized rhesus macaques with an H5N6 vaccine and obtained 30 H5-reactive monoclonal antibodies (mAbs). Three IgG mAbs, 3CF5, 3BG3, and 3BE7, demonstrated potent neutralizing activity against multiple H5Nx viruses and conferred prot...
R1-32-like public antibodies, characterized by shared IGHV1-69/IGLV1-40 usage, are elicited in more than 50% of individuals with COVID-19 and have been implicated in driving recurrent mutations at L452SARS2 and F490SARS2 within their convergent epitope in the SARS-CoV-2 spike receptor-binding domain. These mutations ef...
Chuan-Ying Niu, Xiao-Han Huang, Qi-Hong Yan et al.· PLoS Biology· 0 citations
The structure of PEDV HNXX-strain spike domain B (S1B) is determined and a strain-specific vulnerable site on the PEDV S-trimer is identified, providing insight into how cell-surface membrane fusion activity may influence viral entry pathway selection and antibody neutralization efficacy.
Jian-Bo Liu, Sheng Wang, Zi-Mu Li et al.· bioRxiv· 0 citations
This work pioneers the development of CA-targeted degraders, providing a framework for next-generation anti-HIV therapies with high potency and resistance barriers, via a proteasome-driven pathway.
Mei Wang, Ze-Yu Peng, Yang Zhou et al.· Journal of Medicinal Chemist...· 0 citations
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