Open access
Jul 2026
A hybrid system enables plasmid copy number control in yeast
A programmable PCN platform for S. cerevisiae based on the endogenous 2μ plasmid achieves up to 20 copies per cell with enhanced homogeneity and stability and establishes a well quantified PCN regulation toolkit for yeast, addressing instability from multiple copies and enabling gene dosage control across DNA, RNA, and...
Anni Li, Q. Zhao, Zhu Yang et al.
· Nature Communications · 0 citations