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Author

Xiaolong Chu

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Oct 2026

The identification of SiTRAF suggests the presence of a functional MyD88-TRAF signaling axis in the sea urchin Strongylocentrotus intermedius.

Tumor necrosis factor receptor-associated factors (TRAFs) are key signaling proteins involved in cellular innate immune pathways. However, knowledge of TRAF genes in echinoderms remains limited. We cloned a novel TRAF gene (SiTRAF) from the sea urchin Strongylocentrotus intermedius. The full-length open reading frame o...

Feng-Cheng Liu, Tong Liu, Xiao-Long Chu et al. · 0 citations
Jul 2026

Scallop Toll-like Receptor Engages in Complex Interactions with Diverse MyD88 Proteins and Orchestrates Host Innate Immune Responses.

The identification of a novel TLR gene in Chlamys farreri and analysis of its immune functions expand the knowledge of the role of TLR in mollusk immunity and may provide evidence for selecting disease-resistant scallops for cultivation.

Jilv Ma, Feng-Cheng Liu, Zi-Hao Zhang et al. · 0 citations
Aug 2026

The versatile TRAF3 from sea urchin (Strongylocentrotus intermedius) interacts with MyD88 and regulates host immunity.

SiTRAF3 is identified as a pivotal scaffold protein in the echinoid innate immune system, as it significantly drove the promoter activities of nuclear factor kappa-B, activator protein-1, signal transducer and activator of transcription 3, along with multiple inflammatory cytokines and interferon-related elements.

Xiao-Long Chu, Feng-Cheng Liu, Yingying Liu et al. · 0 citations
Jul 2026

Newly identified TRAF7 interacts with TAK1 and regulates immune response in Chlamys farreri.

This study provides a new perspective for understanding the evolutionary conservation and species specificity of molluscan innate immune signaling pathways and offers important theoretical support for further comprehension of the molecular mechanism of scallop immune defense and promoting the green control of aquatic d...

Xiaoxue Lin, Zihao Zhang, Xiaolong Chu et al. · 0 citations

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