Author

Xiaolu Cui

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Review Oct 2026

The Impact of the Tumor Microenvironment on Immune Checkpoint Inhibitor Resistance in Prostate Cancer: Mechanistic Insights and Therapeutic Strategies.

While immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape for melanoma and lung cancer, their efficacy in prostate cancer (PCa) remains limited. This therapeutic resistance is linked in part to the "cold" immunophenotype of PCa, which is orchestrated by a highly immunosuppressive tumor micro...

Si-Yu Zhou, Yi-Fan Bi, Zi-Yi Xiong et al. · Critical reviews in oncology... · 0 citations

Review Open access Jul 2026

Tumor-associated macrophages and lineage plasticity in prostate cancer: from established myeloid programs to emerging spatial hypotheses

This review synthesizes established and emerging evidence linking TAM heterogeneity to prostate cancer lineage plasticity and outlines an evidence-aware translational roadmap for TAM-directed therapy, emphasizing independent cohort validation, protein-level spatial confirmation, functional perturbation, and biomarker-g...

Jia Li, Jinling Li, Yuechao Zhao et al. · Frontiers in Immunology · 0 citations