Xiao-Ping Lv

Engineering osteoporosis-related bone organoids: a mechanism–module–functional readout framework for disease modelling and biomarker translation

Osteoporosis is a systemic skeletal disorder characterised by reduced bone mass, microarchitectural deterioration and increased fracture risk. Its pathogenesis extends beyond an imbalance between bone formation and resorption and involves osteoimmune dysregulation, vascular insufficiency, oxidative and inflammatory str...