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Xiao-Qi Hong

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Open access Sep 2026

Lipotoxicity-induced ER-mitochondrial hypercoupling activates the mtDNA-cGAS-STING-NF-κB axis to drive follicular arrest in metabolically compromised PCOS

Polycystic ovary syndrome (PCOS) represents a major cause of anovulatory infertility worldwide, yet the mechanistic nexus linking metabolic perturbations to follicular microenvironment deterioration remains elusive. This study uncovers a novel pathogenic axis wherein lipotoxicity in metabolically compromised PCOS (M-...

Ming-Rui Xue, Qi Zhu, Shu-Li Zhang et al. · 0 citations

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