Open access
Oct 2025
TRPM2 is a direct pain transducer
Chronic pain results from maladaptive interaction between the immune and nervous systems. TRPM2 channels in immune cells (immune TRPM2) are believed to facilitate chronic pain by indirectly promoting immune-inflammatory responses. Whereas TRPM2 in sensory neurons (neuronal TRPM2) acts as a warmth sensor critical to sen...
Linda Varghese, M. Alizada, Jin-Quan Yang et al.
· bioRxiv · 1 citation