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Author

Xiao‐Tong Yan

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Sep 2026

A Progression-Associated Tumor-Reactive T-Cell Signature Predicts Immunotherapy Response and Reveals ICOS-High CD8 T-Cell Functional States in Head and Neck Squamous Cell Carcinoma.

Immune checkpoint blockade has improved outcomes for patients with head and neck squamous cell carcinoma (HNSCC), but reliable biomarkers for predicting therapeutic response remain limited. Tumor-reactive T-cell states are increasingly recognized as critical determinants of antitumor immunity; however, progression-asso...

Shao-Qian Zhang, Xiao-Tong Yan, Xi-Chen Dong et al. · 0 citations
Review Aug 2026

Functional regulation of midkine (MDK) and its link to cancer.

A comprehensive overview of the functional regulation of MDK in cancer is provided, summarizing its molecular signaling pathways, contributions to tumor microenvironment remodeling, and involvement in therapeutic resistance.

D. Wusiman, Xue-Zeng Yang, Xiao-Tong Yan et al. · 0 citations
Review Open access Jul 2026

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

This review comprehensively examines the current evidence for diverse biomarkers predictive of HNSCC response to anti‐PD‐1/PD‐L1 therapy, including but not limited to PD‐L1 expression, tumor mutational burden, features of the tumor microenvironment (TME), and circulating biomarkers.

Xiao‐Tong Yan, Zhaohong An, C. An · 1 citation

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