Xiao Wang

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

ABSTRACT Congenital hypothyroidism (CH) is a prevalent endocrine disorder associated with cerebral hypogyrification in neonates and young children, yet the vulnerable cell types and underlying molecular mechanisms remain elusive. Using a gyrencephalic CH pig model, we observed cerebral atrophy and cortical hypogyrifica...