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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Xiao-Xian Shi

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Open access Sep 2026

Follistatin drives AR-independent prostate cancer through BMP signaling inactivation and microenvironmental remodeling.

Resistance to androgen receptor (AR)-targeted therapies remains a major clinical challenge in advanced prostate cancer. Here we identify follistatin (FST), TGFβ superfamily antagonist, as a key driver of AR-independence and treatment resistance. During anti-AR therapy, cancer cells progressively lose the positive feedb...

Xiao-Xian Shi, Zu-Yan Fan, Min Qu et al. · 0 citations

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