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Author

Xiao-Xiao Wu

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Sep 2026

Rosmarinic Acid Inhibits β-Sheet and β-Hairpin Formation in Human Islet Amyloid Polypeptide Dimers by Stabilizing Localized C-Terminal Motifs: An REMD Study

The misfolding of human islet amyloid polypeptide (hIAPP) into soluble oligomers is a primary pathological event in type 2 diabetes, with the early dimerization process representing a critical pharmacological target. Here, we investigate the molecular mechanism by which rosmarinic acid (RA) counteracts full-length hI...

Gang Wang, Xin-Qiu Zhu, Zi-Qian Zhao et al. · 0 citations

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