Author

Xiao-Xin Chen

2 papers indexed here

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Open access Sep 2026

Pharmacokinetics, Safety, and Exploratory Efficacy of Onradivir in Children with Acute Uncomplicated Influenza: A Multicenter, Dose-Ranging, Phase 2 Study.

INTRODUCTION Seasonal influenza brings high morbidity and mortality in children, with current antivirals limited by low efficacy and rising resistance. Onradivir (ZSP1273), a polymerase basic protein 2 (PB2) cap-binding inhibitor effective in adults, remains unstudied in pediatric influenza A. This phase 2 study evalua...

Q. Qin, Chun-Ying Ma, Yi-Min Yang et al. · Infectious Disease and Thera... · 0 citations

Oct 2026

ZSP1601 is a non-selective phosphodiesterase inhibitor and a clinical drug candidate for the oral treatment of metabolic dysfunction-associated steatohepatitis.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health challenge. Its advanced stage, metabolic dysfunction-associated steatohepatitis (MASH), involves complex processes such as metabolic dysregulation, inflammation, and fibrosis. Existing treatments mainly target steatosis but have...

Miao Liu, Zhuo-Wei Liu, Ying Leng et al. · Biochemical and Biophysical... · 0 citations