Cell-Free Regenerative Therapies for Wound Healing and Skin Repair: The Emerging Role of Adipose-Derived Stem Cell Extracellular Vesicles.
SIGNIFICANCE Chronic wounds, burns, radiation-injured wounds, and pathological scars remain major clinical challenges despite advances in wound care. Adipose-derived stem/stromal cell extracellular vesicles (ADSC-EVs) offer a cell-free strategy for delivering bioactive proteins, lipids, and nucleic acids across multipl...