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Author

Xiaoxue Wang

2 papers indexed here

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Oct 2026

Structural evolution of an ancient nucleotidyltransferase underlies divergence of AbiE antitoxins.

Type VII toxin-antitoxin (TA) systems neutralize toxins through antitoxin-mediated post-translational modification (PTM), with the oligoAMPylation-based HepT/MntA and phosphorylation-based AbiE systems representing the most prevalent families. Although the AbiE TA system from Mycobacterium tuberculosis is known to empl...

Tian-Lang Liu, Ran Chen, Kai-Hao Tang et al. · 0 citations
Review Aug 2026

Tripartite toxin-antitoxin systems: expanding the paradigm of molecular interplay and antiphage defense.

This review compares tripartite TA systems [TA-chaperone (TAC), TA-regulator (TAR), dual-antitoxin, and dual-toxin systems] with bipartite systems, summarizing their neutralizing mechanisms and phage-triggered activation pathways.

Yun-Xue Guo, Pierre Genevaux, Xiaoxue Wang · 0 citations

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