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Xiao-Ya Xue

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Open access Aug 2026

Combined hydrogen and oxygen therapy attenuates vascular cognitive impairment in rats via gut microbiota-derived SCFA-GPR41/PI3K/Akt/Nrf2 signaling

Vascular cognitive impairment (VCI), a consequence of chronic cerebral hypoperfusion (CCH), is characterized by neuroinflammation and neuronal apoptosis. Hydrogen-rich and hyperoxygenated solution (HHOS) may attenuate CCH-induced brain injury through antioxidant, anti-inflammatory, and gut microbiota-modulating mec...

Xin-Lei Fu, Meng-Zhuo Ma, Yujing Zhang et al. · 0 citations

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