Review
Open access
Oct 2026
Dickkopf-3 (DKK3) in cardiovascular diseases: from a stress-responsive biomarker to a potential therapeutic target
Dickkopf-3 (DKK3) is a secreted glycoprotein that functions as a context-dependent modulator of the Wnt/β-catenin and transforming growth factor-beta (TGF-β) signaling pathways. Originally studied in development and cancer, DKK3 has recently emerged as a key stress-responsive factor. It is released by epithelial and ot...
Xiao-Yan Fu, Jian-Feng Dai, Xiao-Qian Wang et al.
· Frontiers in Pharmacology · 0 citations