Open access
Oct 2026
ZC3H14 phosphorylation is required for nuclear speckle assembly during zygotic splicing activation in mice.
Following zygotic genome activation (ZGA) in embryos, nuclear speckles, which are subnuclear domains where pre-mRNA undergoes splicing, are reassembled in a process called zygotic splicing activation (ZSA). ZSA is vital for early development, but its regulation is poorly understood. This study identifies the RNA-bindin...
Yang Wang, Hua Zhang, Zhe-Wei Hu et al.
· EMBO Reports · 0 citations