Exploring the Toxicological Impacts of DOTP Exposure on Pulmonary Arterial Hypertension via Network Toxicology, Virtual Knockout, Molecular Docking and Experimental Validation
Environmental factors are significant contributors to the pathogenesis of pulmonary arterial hypertension (PAH). Di-(2-ethylhexyl) terephthalate (DOTP) is a plasticizer widely used in daily life and poses potential health hazards. Nevertheless, the molecular mechanisms underlying PAH development following long-term DOT...