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Xiao-Zheng Li

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Open access Oct 2026

Exploiting inosine as a distinctive cleavage site for deriving a highly specific RNA-cleaving DNAzyme

Most RNA-cleaving DNAzymes are limited to cleaving between combinations of the four canonical ribonucleotides. Through in vitro selection, we isolated ICD11-1T, a DNAzyme that selectively cleaves at inosine, a non-canonical RNA modification generated by adenosine deamination. ICD11-1T cleaves inosine-containing substra...

Shu-Sen Xiao, Pan Jia, Kai Niu et al. · 0 citations

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