A biomimetic supramolecular hydrogel enabling sequential dual-agent release reprograms the inflammatory microenvironment for sciatic nerve regeneration.
Peripheral nerve injury (PNI) repair is fundamentally hindered by a dysregulated inflammatory microenvironment and insufficient bioactive components. Conventional hydrogels fail to concurrently integrate dynamic responsiveness, neural biomimicry, and inflammation regulation. Herein, we engineered a biomimetic supramole...