Xiaofei Zhu

Advances in combinatorial CRISPRi screening and applications: Decoding higher-order interactions for next-generation microbial cell factories in synthetic biology.

This review details the optimization of carbon flux in microbial cell factories to circumvent production bottlenecks, alongside the elucidation of protective multigenic networks against severe environmental stress, and provides a comprehensive guide for decoding complex traits and driving rational designs of next-generation cell factories.