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Xiaohui Zhang

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Jul 2026

Synergistic oncogenesis in human cholangiocytes: IDH1 mutation and the biliary microenvironment to drive early transformation and a targetable metabolic dependency in patient-derived organoids.

A novel, physiologically relevant in vitro model that recapitulates the synergistic oncogenesis driven by IDH1 R132C mutation and microenvironmental stress in early CCA is established and provides a preclinical platform for identifying and testing interceptive strategies aimed at reversing or halting early cholangiocarcinogenesis in high-risk settings.

Ziye Chen, Qingru Song, Jinxin Wang et al. · 0 citations