Author

Xiaolin Wei

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Open access Jul 2026

TRIM27-Cas9-loaded EVs suppress HCC proliferation and enhance responsiveness to anti-PD-1 therapy by promoting ACSL4-mediated ferroptosis.

It is suggested that TRIM27 confers ferroptosis resistance via facilitating K48-linked ubiquitination and subsequent proteasomal degradation of ACSL4 and developed TRIM27-Cas9-loaded EVs with robust editing efficiency.

Jie Wen, Zhihui Wang, Zhirui Zeng et al. · Cell Death and Differentiati... · 1 citation