Aug 2026
Mechanistic basis of G595R-mediated resistance to entrectinib in TRK kinase: a structural-energetic perspective
These findings provide a mechanistic explanation for entrectinib resistance at atomic resolution and illustrate how a single-point mutation can trigger long-range perturbations in protein dynamics and interdomain communication.
Min-Yu Li, Xu Jiang, Tingting Du et al.
· Journal of Molecular Modelin... · 0 citations