Author

Xiaoshan Zhao

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Open access Aug 2026

Lactylation-dependent DDX18 nucleolar escape regulates CD44 mRNA stability to drive fibrotic progression in kidney injury.

Following acute kidney injury (AKI), a substantial subset of patients experiences an irreversible progression to chronic kidney disease (CKD), yet the molecular determinants governing this maladaptive transition remain elusive, and effective clinical interventions are lacking. Here, we identify lactate as a key metabol...

Li-Jun Dong, Jingwen Xie, Mengyuan Tao et al. · Journal of Clinical Investig... · 0 citations

Open access Sep 2026

Limonin ameliorates hyperuricemia-induced cognitive impairment through modulation of microglial HIF-1α-driven neuroinflammation.

BACKGROUND Hyperuricemia (HUA), a highly prevalent metabolic disorder, is increasingly linked to cognitive impairment. Limonin (LIM), a natural compound with anti-inflammatory and neuroprotective properties, has the therapeutic benefits, but its underlying mechanisms remain unclear. PURPOSE This study aimed to invest...

Jie Chen, De-Xian Li, Xiao-Hu Chen et al. · International Immunopharmaco... · 0 citations