Immune checkpoint blockade has improved outcomes for patients with head and neck squamous cell carcinoma (HNSCC), but reliable biomarkers for predicting therapeutic response remain limited. Tumor-reactive T-cell states are increasingly recognized as critical determinants of antitumor immunity; however, progression-asso...
Midkine (MDK) is a heparin-binding growth factor that is minimally expressed in most adult tissues but markedly upregulated in a wide range of malignancies. Accumulating evidence positions MDK as a multifunctional signaling hub that orchestrates tumor progression through its pleiotropic effects on cancer cells and the...
D. Wusiman, Xue-Zeng Yang, Xiao‐Tong Yan et al.· Cancer Genetics· 0 citations
This review comprehensively examines the current evidence for diverse biomarkers predictive of HNSCC response to anti‐PD‐1/PD‐L1 therapy, including but not limited to PD‐L1 expression, tumor mutational burden, features of the tumor microenvironment (TME), and circulating biomarkers.
Xiao‐Tong Yan, Zhaohong An, C. An· World Journal of Otorhinolar...· 1 citation
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