Discovery of FM-2665 as a Potent Arylpyrazole Insecticidal and Acaricidal Candidate: Rational Design via Pyridine Bioisosterism and Terminal Alkyl Optimization.
FM-2665 (A14) showed the highest overall activity and represents a promising lead for further optimization and safety evaluation, and molecular docking and DFT calculations suggested that additional predicted contacts involving Gln96 and Val126, together with a narrower HOMO-LUMO gap, may contribute to the observed str...