Author

Xiaoyan Tang

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Open access Jul 2026

Systematic Position Mapping of Split CRISPR‐Cas12a Activators Enables Highly Sensitive miRNA Detection and Cancer Cell Stratification

This work systematically map over 200 split DNA activator configurations by introducing nicks at every position across both strands, revealing that target strand nicks suppress activity with position‐dependent severity, while non‐target strand nicks enhance activity.

Xiaoyan Tang, Zhe Li, Yu-Ning Lu et al. · Advancement of science · 0 citations