Breast cancer is the most common malignancy in women, and pharmacotherapy is the cornerstone of multidisciplinary care. However, drug resistance severely impairs therapeutic efficacy and patient prognosis. Circular RNAs (circRNAs) have become a key focus in breast cancer chemoresistance due to their high stability and...
Current mechanistic insights into miRNA- mediated regulation of the aforementioned signaling highways are synthesized, context-dependent controversies arising from tumor heterogeneity and microbial influence are highlighted, and rational combinatorial strategies that may accelerate the development of next-generation, h...
Liu-Shan Wei, Jia Yu, Yan Hu et al.· Current Cancer Drug Targets· 0 citations
In vivo studies have shown that compound 9o can inhibit tumor growth and reduce the levels of HIF‐1α and glycolysis rate‐limiting enzyme HK2 in HCT‐116 tumor‐bearing mice, and the acute toxicity results also demonstrated the safety of compound 9o in vivo.
Qixian Yang, Jing Zhang, Meijing Liu et al.· Drug development research (P...· 0 citations
Results highlight lncRNA ABCA9-AS1 as a novel and promising prognostic biomarker that promotes gastric cancer progression by acting as a ceRNA to modulate the miR-497-5p/KIF23 axis.
Yiwen Wu, Yiniu Xia, Hanyu Liu et al.· Current Cancer Drug Targets· 0 citations
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