Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) arise from overlapping metabolic stress, gut-derived inflammatory input, immune activation, and fibrotic remodeling. Bile acids participate in cholesterol metabolism and lipid absorption, and the...
Yang-Xuan Du, Lin Qi, Yunze Shi et al.· Frontiers in Medicine· 0 citations
A macrophage death-mode bifurcation framework centered on caspase-8 activity, RIPK1 ubiquitination, mitochondrial stress, oxidative stress thresholds, and autophagic flux is proposed to provide a basis for future studies integrating cell-death regulation, cholesterol transport, and plaque stability.
Yanan Bian, Xiao-Yang Hu· Frontiers in Cardiovascular...· 0 citations
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