Open access
Jul 2026
Maximizing the productivity of co-transcriptional in vitro transcription
An optimized co-IVT process that achieves a yield of more than 26 g/L while maintaining capping efficiency of over 99.5%, and achieving a 30-fold reduction in double-stranded RNA (dsRNA), the most critical process-related impurity, substantially improves mRNA production efficiency and enhance mRNA quality, thereby acce...
Wei He, Kun-Kun Zhang, Guiying Ji et al.
· bioRxiv · 0 citations