The integration of diagnostic imaging and targeted therapy into unified theranostic platforms represents a paradigm shift in precision medicine. Yet, clinical efficacy is often hampered by suboptimal pharmacokinetics that impair target-specific uptake and increase systemic exposure, representing a persistent obstacle t...
Kaiwen Zhang, Tian-Xue Han, J. Pei et al.· Advanced Drug Delivery Revie...· 0 citations
Tumor microenvironment (TME) is a metabolically dynamic niche where dysregulated purinergic signaling plays a pivotal role in shaping antitumor immunity. Although immunogenic cell death (ICD) induces the release of extracellular ATP (eATP) to initiate immune activation, the overexpression of ectonucleotidases rapidly d...
Ming Yang, Zhichu Xiang, Mengyao Zhao et al.· Small· 0 citations
Non-small cell lung cancer (NSCLC) remains difficult to cure owing to therapy resistance and immune evasion that limits durable therapeutic responses. Here, we report a carrier-free nanoregulator (CE NPs) formed by co-assembling chlorin e6 (Ce6) with a covalent c-Myc inhibitor (EN4), enabling photo-immunotherapy that c...
An inherent T cell-activating polymer-lipid nanoparticle that enables ligand-free, efficient mRNA transfection and activation of T cells in vivo, and provides a clinically translatable approach for in vivo CAR T cell generation.
Next-generation personalized cancer vaccines are advancing the transition from reactive treatment to proactive, precision-controlled cancer immunotherapy, and when integrated with artificial intelligence for antigen selection and multiomics for patient stratification, these platforms accelerate vaccine design and impro...
L. Ye, GuoWei Zhao, Jiaxiu Ma et al.· Signal Transduction and Targ...· 1 citation
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