Author

Xiazhou Fu

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Open access Aug 2026

MTCH2 acts as a novel inhibitory receptor to suppress germ cell mitophagy by tethering BECN1, thereby maintaining mitochondrial homeostasis and male fertility

These findings establish MTCH2 as an essential negative regulator of mitophagy that partners with BECN1 to maintain mitochondrial homeostasis, thereby ensuring normal spermatogenesis and male fertility.

Mengxing Cai, Rui-Fang Ren, Huiling Shu et al. · Cell Death & Disease · 0 citations