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Author

Xiexing Wu

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Aug 2026

Protein phosphatase 2A regulates nucleus pulposus autophagy and aggravates degeneration via the AKT/mTOR pathway.

Protein phosphatase 2A, a serine-threonine phosphatase, plays a pivotal role in diverse cellular processes in eukaryotic cells. In this research, we observed a significant increase in PP2Ac expression in NPCs with higher degeneration grades. In vitro experiments demonstrated that following the induction of NP cell dege...

Yi-Jie Liu, Yu-Jie Wang, Hong Zhou et al. · 0 citations
Jul 2026

The USP5-MATN3 axis in nucleus pulposus cell senescence: A Deubiquitination mechanism protecting against intervertebral disc degeneration.

This study clarifies the molecular mechanism by which the USP5/MATN3 axis regulates cellular senescence and affects IVDD progression, opening up new potential targets for the intervention strategy of IVDD.

Chunyang Fan, Jie-yun Xia, Yao Zhang et al. · 0 citations

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