A facile and versatile antifouling sensor capable of assaying targets in diverse biological fluids was developed based on engineered peptoids with improved proteolytic stability. As peptidomimetics featuring N-substituted glycine backbones, the engineered peptoids are anchored by d-Cys, linked by (d-Pro)4 fragment, a...
Min Chen, Meng-Yan Li, Gui-Xiang Wang et al.· Analytical Chemistry· 0 citations
A β-d-glucose (β-d-Glc) moiety is introduced at the C-terminus of sensor-integrated peptide sequences to markedly enhance peptide–water interactions, reduce nonspecific adsorption, and protect the peptide backbone from proteolytic cleavage.
Yan-Xin Li, Yinan Zhan, Jie Yang et al.· Chemical Science· 0 citations
S100B is a clinically important biomarker for traumatic brain injury and neurodegenerative diseases, necessitating the development of sensitive and reliable analytical methods for its determination in complex biological fluids susceptible to potential biofouling and electroactive interference. Herein, we report a robus...
Feng Xu, Yao-Yao Xiao, Gao-Chao Fan et al.· Analytical Chemistry· 0 citations
An antifouling electrochemical biosensor is constructed, which effectively resists nonspecific adsorption while maintaining high enzymatic stability, enabling the direct detection of carbohydrate antigen 15-3 in human serum with a detection limit of 2.64 mU·mL-1.
Shuyu Jiang, Shi-Cheng Liu, Zhen Song et al.· Analytical Chemistry· 0 citations
The reliable electrochemical detection of immunoglobulin G (IgG) in complex biological fluids is severely hampered by nonspecific protein fouling and enzymatic degradation. Inspired by natural lasso peptides, we engineer a multifunctional lasso-like peptide (LaP) composed entirely of D-amino acids that uniquely integra...
