Author

Xin-An Zhu

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Review Open access Jul 2026

Pharmacological Effects and Molecular Mechanisms of Lignans in the Treatment of Alzheimer’s Disease

Alzheimer’s disease (AD) is a complex, multifactorial neurodegenerative disorder whose core pathological hallmarks include Aβ aggregation, tau hyperphosphorylation, chronic neuroinflammation, oxidative stress, mitochondrial dysfunction, and gut microbiota dysbiosis. Lignans, a class of naturally occurring polyphenolic...

Li-Meng Sun, Xin-An Zhu, Chunyan Fan et al. · Molecules · 0 citations

Jul 2026

Mechanistic and functional study of lncRNA SNHG3/miR-128-3p/UBR5 axis in neuroinflammation in Alzheimer's disease.

Neuroinflammation assumes a pivotal role in Alzheimer's disease (AD) pathogenesis. Long noncoding RNAs (lncRNAs) regulate neuroinflammation through a competitive endogenous RNA (ceRNA) mechanism. This study aimed to explore the mechanism of SNHG3/miR-128-3p/UBR5 axis in AD associated neuroinflammation. SNHG3, miR-128-3...

Xin-An Zhu, Huijie Lu, Yumei Liu et al. · The journals of gerontology.... · 0 citations