Imaging of Proteoforms in Biological Tissues with High Spatial Resolution Using Nano-DESI Mass Spectrometry.
Nanospray desorption electrospray ionization (nano-DESI) is an ambient mass spectrometry imaging (MSI) technique that enables molecular imaging of individual proteoforms in tissue sections. Nano-DESI generates multiply charged ions of intact proteoforms directly from the tissue, which facilitates their identification u...