Author

Xin-Feng Yang

3 papers indexed here

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Open access Sep 2026

Integrated untargeted and targeted metabolomics identifies and validates urinary bile acid biomarkers for the diagnosis of intrahepatic cholestasis of pregnancy

Background Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-specific liver disorder and is characterized by unexplained pruritus and elevated serum bile acid levels, typically in the third trimester. Excessive bile acid accumulation is associated with maternal discomfort and adverse fetal outcom...

Hai-Yue You, Jing-Yi Gao, Xin Ning et al. · Frontiers in Endocrinology · 0 citations

Open access Sep 2026

Enhancing the Identification of NHS Ester-Mediated Lysine-Cysteine Cross-Linking via Reduced Trypsin Digestion Time

Chemical cross-linking mass spectrometry (XL-MS) is a powerful technique for elucidating protein structures and interactions, with NHS ester-based cross-linkers being the most widely used. Traditionally, NHS esters are considered highly specific for primary amines; although their reactivity toward cysteine thiols has b...

Xin-Feng Yang, Ao-Cheng Hou, Qian Sun et al. · bioRxiv · 0 citations

Open access Sep 2026

Type I collagen promotes triple-negative breast cancer progression through a UBE2V1–ACSL5 regulatory axis

Introduction Triple-negative breast cancer (TNBC) is characterized by aggressive behavior and extensive extracellular-matrix remodeling. Type I collagen (COL I), a major stromal component, promotes tumor progression, but the downstream tumor-cell mechanisms remain incompletely defined. We investigated whether COL I reg...

Lu Liu, Yi-Da Wang, Hai-Yue You et al. · Frontiers in Oncology · 0 citations