Xin-Gen Zhu

SDHB deficiency promotes renal fibrosis by triggering mtRNA leakage and activating the RIG-I-MAVS pathway.

While mutations in tricarboxylic acid (TCA) cycle enzyme succinate dehydrogenase B (SDHB) are well-established drivers of renal cell carcinoma via the accumulation of the oncometabolite succinate, its precise role in renal fibrosis remains entirely unexplored. In this study, we demonstrate that SDHB is down-regulated i...